→ When researchers blocked IL-17a or altered the maternal microbiome via fecal transplant, these behavioral patterns shifted
Critically:
✓ This occurred in genetically susceptible mouse strains—not all mice
✓ The effect depended on a specific immune-microbiome interaction during a precise developmental window
✓ Researchers explicitly state these findings do not equate to human autism causation
As Dr. Lukens noted: "The maternal microbiome helps calibrate how the offspring's immune system will respond to challenges—a process that may indirectly influence neurodevelopment."